Indeed, the mTOR signaling pathway, which is a key negative regulator of autophagy and hyperactivated in AD brains [38], was activated both in 12-month-old AppNL-F and AppNL-G-F mice (FDR = 0.0167 for AppNL-F; FDR = 0.0121 for AppNL-G-F) (Fig. 1E). The gene discussed is MTOR; the disease is Alzheimer disease.