Furthermore, this result persisted in a multivariate analysis (low versus high Ang-2 expression; HR = 0.49; 95% confidence interval [CI] 0.31–0.78; p = 0.003) adjusted for age, sex, stage, adjuvant therapy, radical (R0) surgery, and tumor markers CA19-9, CRP, and CEA (Table 3). This evidence concerns the gene CEACAM5 and neoplasm.