Here, by utilizing high-throughput RNA-Seq-based screening and the related reports on CD97 promotes EMT and metastasis of ovarian cancer cells by activating the JAK2/STAT3 pathway 14, we found that the prometastatic factor CD97 could be a critical mediator of IL-8-induced promotion of EMT. The gene discussed is CXCL8; the disease is ovarian carcinoma.