CXCL8 and intrahepatic cholangiocarcinoma: Studies have shown that the expression of IL-8 is significantly correlated with the progression and prognosis of various cancers, such as ovarian cancer6, breast cancer7, bladder epithelial cancer8, small cell lung cancer9, etc. As the primary cytokine, IL-8 is implicated in tumorigenesis, but its exact impact on ICC is not clear.