In order to demonstrate the expression levels of IL-8 and CD97 in different grades, we chose ICC tissues with different histological differentiation degree, and IL-8 and CD97 were high expressed in poorly differentiated tissues and low expression in well differentiated tissues in Fig. 1D. The overall survival probability of patients stratified by IL-8 or CD97 expression was plotted based on datasets of 125 ICC patients. The gene discussed is CXCL8; the disease is intrahepatic cholangiocarcinoma.