The expression of IL-8 and CD97 was significantly correlated with histological differentiation (P = 0.001 and 0.007), lymph node metastasis (P = 0.026 and 0.001), and vascular invasion (P = 0.001 and 0.001), all suggesting the aggressive status of ICC. The gene discussed is CXCL8; the disease is intrahepatic cholangiocarcinoma.