FLI1 being a regulator of the SCLC NE subtype, MITF being a regulator of the NON-NE subtype, and ASCL1 being a destabilizer of the NON-NE subtype and regulator of the NE subtypes34 suggest that this pathway has a potential role in NON-NE to NE subtype transition. This evidence concerns the gene ASCL1 and small cell lung carcinoma.