Overall, the SCLC subtypes have been classified into four classes SCLC-A (also labeled as NE), SCLC-N (also labeled as NEv1), SCLC-Y (also labeled as NON-NE), and SCLC-P defined by the expression of the transcription factors ASCL1 (A), NEUROD1 (N), YAP1(Y), and POU2F3 (P), respectively29–37. Here, POU2F3 is linked to small cell lung carcinoma.