We compared non-infected Jurkat T cells with single round HIV-1(i)GFP infected T cells and quantified a significant 10-fold increase of membrane-bound Arpin localization surface density upon HIV-1 infection, from 62 ± 7 localizations per μm2 in non-infected cells to 626 ± 65 localizations per μm2 in infected cells (n = 100 different areas of 1 μm2) (Fig. 7D). Here, ARPIN is linked to HIV-1 infection.