To determine the effect of mPGES-2 on AKI, we obtained mPGES-2 wild-type (WT, Ptges2+/+) and mPGES-2-knockout (KO, Ptges2−/−) mice, and found that mPGES-2 deficiency had no significant effect on the expression of mPGES-1 and cPGES, the other two PGE2 synthases (Supplementary Fig. 1A–C). Here, PTGES2 is linked to acute kidney injury.