An analysis of ferroptosis markers revealed that mPGES-2 deficiency decreased the level of p53, whereas increased the expression of SLC7A11 and GPX4 (Fig. 4I, J; Supplementary Fig. 3D), indicating that mPGES-2 plays a key role in mediating ferroptosis in AKI. The gene discussed is PTGES2; the disease is acute kidney injury.