Importantly, iMCD can be further classified into two distinct subtypes: iMCD with thrombocytopenia, anasarca, fever/elevated C-reactive protein (CRP), reticulin myelofibrosis, renal dysfunction, and organomegaly syndrome (iMCD-TAFRO) and iMCD-not otherwise specified (iMCD-NOS)1,2. The gene discussed is CRP; the disease is Abnormal renal physiology.