Xenotransplantation of unmanipulated LN cells from patients with iMCD-NOS resulted in cachexia with efficient reconstitution of human hematopoietic cells, whereas transplantation of T cell-depleted LN cells from identical patients failed to reconstitute human hematopoiesis in the spleen (Fig. 3b). The gene discussed is NOS1; the disease is Cachexia.