First, we transplanted 1.0–3.0 × 106 LN cells from seven independent patients with reactive lymphadenopathy (n = 3) and lymphoma (n = 4) (C1, C2, C3, C4, C5, C6, and C7) and three independent patients with iMCD-NOS (P1, P2, and P3) into the 2.2 Gy irradiated NOD.Cg-PrkdcscidIl2rgtm1Wjl/Sz (NSG) mice via tail vein injection (Fig. 1a). The gene discussed is CTSG; the disease is lymphoma.