MAPT and early-onset autosomal dominant Alzheimer disease: On the other hand, SRPK2 has been widely linked to AD (Alzheimer’s disease) by phosphorylating tau, a neuronal microtubule-associated protein, and inducing its polymerization, thus leading to supression of tau-dependent microtubule polymerization, and inhibiting axonal elongation in neurons [30, 32, 33].