Finally, in line with the ability of fasting to increase ABCG1 expression in tumours in vivo and thus, conceivably, to enhance cholesterol efflux to mature HDLs, we found the administration of HDLs to Capan-1 xenograft-bearing mice to increase fasting’s ability to reduce intratumour cholesterol and to slow tumour growth (Fig. 5e–g). The gene discussed is ABCG1; the disease is neoplasm.