SQLE and colorectal cancer: Consistent with this hypothesis, we found FMCC to also confer strong cytotoxic activity to itraconazole, another 14α-demethylase inhibitor, simvastatin, a 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) inhibitor and to the squalene epoxidase (SQLE)16,17 inhibitors, terbinafine, butenafine and liranaftate in PK9 and Capan-1 PDAC cells and in HCT116 colorectal cancer (CRC) cells (Fig. 1d, Supplementary Fig. 1a-e).