Consistent with the in vivo evidence that fasting stimulates ABCG1, but not ABCA1 expression, we observed that in vitro, cholesterol efflux from both HCT116 and MCF7 cancer cells only increased under FMCC when HDLs, but not ApoA-I were used as acceptors (Fig. 5d). The gene discussed is ABCA1; the disease is cancer.