Recent studies elaborated that the administration of PD-L1-overexpressed exogenous cells or cell-derived extracellular vesicles could reduce infiltrating autoreactive T cells and promote the recruitment of infiltrating regulatory T cells (Tregs) to reverse early-onset hyperglycemia in nonobese diabetic (NOD) mice, prevent multiple sclerosis in autoimmune encephalomyelitis, and ameliorate ulcerative colitis and psoriasis12–16. This evidence concerns the gene CD274 and Hyperglycemia.