Several lines of evidence indicate that high B4GALT1 expression is associated with poor survival of patients and promotes malignant behaviors in several cancer types, such as lung cancer [25], bladder cancer [26], pancreatic ductal adenocarcinoma [27], renal cancer [28], glioblastoma [29], leukemia [30], etc. Despite important biological functions of galactosylation and high expression of B4GALT1 in the liver, the role of B4GALT1 in HCC still remains elusive. This evidence concerns the gene B4GALT1 and cancer.