Mechanistic investigation indicated that downregulation of B4GALT1 enhanced HCC cell adhesion to laminin and integrins α6 and β1, subunits of the laminin receptor, were the main protein substrates of B4GALT1 to mediate the migration and invasion mediated by B4GALT1 knockdown or knockout (Fig. 7). Here, LAMB2 is linked to hepatocellular carcinoma.