Several lines of evidence indicate that high B4GALT1 expression is associated with poor survival of patients and promotes malignant behaviors in several cancer types, such as lung cancer [25], bladder cancer [26], pancreatic ductal adenocarcinoma [27], renal cancer [28], glioblastoma [29], leukemia [30], etc. Despite important biological functions of galactosylation and high expression of B4GALT1 in the liver, the role of B4GALT1 in HCC still remains elusive. The gene discussed is B4GALT1; the disease is glioblastoma.