Therefore, our proposed mechanism by which silencing B4GALT1 promotes cell invasiveness is that low B4GALT1 expression alters N-glycans on integrin β1 and integrin α6, induces a more active conformation of integrin α6β1 heterodimer to enhance cell-laminin adhesion, and in turn increases cell migration and invasion in HCC cells. This evidence concerns the gene B4GALT1 and hepatocellular carcinoma.