TIMP2 and acute kidney injury: This finding supports the NIOSH recommendation to ensure peak core temperature does not exceed 38.0°C in unacclimated workers.7 Peak Δ sCr was correlated with the peak Δ urinary [IGFBP7·TIMP-2], and these variables largely changed in parallel, supporting the use of changes in sCr as a marker of AKI risk in both laboratory and field settings.