HMGB2 and cancer: Here, several growth-associated genes were up-regulated, including RNA helicase (HELLS), PRR11, CDCA8, and DNA topoisomerase 2 (TOP2A), HMGB2, EIF2B4, and CDKN3, which are thought to serve important functions during growth stimulation, many of which are known to be up-regulated in various cancers.