Human mutationsin ADAR cancause Aicardi-Goutièressyndrome (AGS6);60ADAR was the sixth gene identified in which human mutations cause thissyndrome (Table 1).AGS results in inflammation and aberrant high IFN and ISG expression,particularly in the brain, and it presents in children with symptomssimilar to those of a congenital virus infection with high levelsof IFN. This evidence concerns the gene IFNA1 and viral infectious disease.