Human mutationsin ADAR cancause Aicardi-Goutièressyndrome (AGS6);60ADAR was the sixth gene identified in which human mutations cause thissyndrome (Table 1).AGS results in inflammation and aberrant high IFN and ISG expression,particularly in the brain, and it presents in children with symptomssimilar to those of a congenital virus infection with high levelsof IFN. The gene discussed is ADAR; the disease is viral infectious disease.