Further, ATF4 ability to bind to the allelic variants of selected SNPs and activate transcription was validated by EMSA and conventional luciferase assays, and CRISPR/Cas9 technology was used to confirm the regulatory effect of rs532446 (associated to platelet and red blood cell characteristics) on GADD45A and rs7011846 (associated to myocardial infarction) on LPL gene expression in the endogenous genomic context. Here, ATF4 is linked to myocardial infarction.