In addition, SIRT1-deficient mice induce male infertility by inducing spermiogenesis disruption, sperm morphological abnormalities (McBurney et al. 2003; Coussens et al. 2008; Bell et al. 2014) and the inability to display hyperactivated motility (Iniesta-Cuerda et al. 2022a). This evidence concerns the gene SIRT1 and male infertility.