TARDBP and frontotemporal dementia: In keeping with its clinical diversity, the pathology underpinning nfvPPA is heterogeneous: most patients will have a primary tauopathy such as progressive supranuclear palsy, corticobasal degeneration or (uncommonly) Pick’s disease, but a sizeable proportion of cases have TDP-43 or Alzheimer pathology [119, 141, 142].