GRN and frontotemporal dementia: Genetic screening should be considered in younger patients, particularly where there is a suggestive family history of younger onset dementia in a first-degree relative (especially frontotemporal dementia or motor neuron disease), the PPA phenotype is atypical (as a genetic basis may be somewhat more likely in this scenario [148, 149, 153, 158, 159]) and/or there is strikingly asymmetric fronto-temporo-parietal atrophy on MRI (as this may signal a GRN mutation [142, 160]).