Additionally, in spatial transcriptomics data obtained from patients with CKD, we were able to validate the coexpression of HAVCR1, VCAM1, SPP1, and IL34 as the markers for iPT cells in regions with a high extracellular matrix (ECM) production score (fibrosis) (37) (Supplemental Figure 27). This evidence concerns the gene SPP1 and chronic kidney disease.