Additionally, given the well-established ability of human umbilical vein endothelial cells (HUVECs) to form capillary-like structures on Matrigel, we further ascertained that the culture supernatant from BCLAF1-overexpressing HCC cells significantly augmented the capacity of HUVECs to form more mature structures compared to the control groups (Fig. 2J, K). The gene discussed is BCLAF1; the disease is hepatocellular carcinoma.