Transcript levels of several EMT driver genes — e.g., ZEB1, VIM, TWIST1 — were elevated in breast tumors of patients with diabetes (Supplemental Figure 11), and the diabetes-associated transcriptome showed significant overlap with the Hollern_EMT_Breast_Tumor_Up as well as a LIM-Mammary_Stem_Cell_Up signatures in the GSEA MSigDB collection (Figure 4, G and H; FDR = 0.1 and 0.06, respectively). This evidence concerns the gene TWIST1 and breast neoplasm.