To continue our interrogation of the diabetes-associated tumor biology, we generated RNA-Seq–based gene expression profiles for the 3 tumor xenograft models, 73 patient tumors, and 6 human breast cancer cell lines cultured under hyperglycemic conditions (ER+: MDA-MB-175, ZR-7530, and HCC1500; ER–: MDA-MB-157, MDA-MB-231, and MDA-MB-468; all with exception of MDA-MB-231 being cell lines from African American donors). Here, ESR1 is linked to breast carcinoma.