GSTZ1-KO promoted HUVECs’ proliferation, migration, and angiogenesis capacity, while angiogenesis caused by GSTZ1 deficiency was inhibited by 2-ME2, indicating the essential role of HIF-1α in HCC progression upon GSTZ1 depletion (Figure 3, E–G, and Supplemental Figure 3, A–C). This evidence concerns the gene HIF1A and hepatocellular carcinoma.