HIF1A and neoplasm: However, the HIF-1α inhibitor 2-ME2 abrogated the increase in VEGFA, MMP2, and MMP9 induced by GSTZ1 deficiency in orthotopic mouse models, revealing that inhibition of HIF-1α with 2-ME2 substantially reversed tumor growth, MVD, and progression in Gstz1-KO mice (Figure 4, E and F).