Meanwhile, overexpression of ETS2 and ERG has been found in cell line and murine models to cooperate with mutated or knocked-down GATA1 to induce expansion of the megakaryocytic compartment (52, 55, 56), suggesting that the gene dosage of the DSCR, including DYRK1A, contributes to TAM and ML-DS phenotypes but may not be sufficient. Here, DYRK1A is linked to Dravet syndrome.