The requirement for LAMTOR3 in EV71 replication was further confirmed in human rhabdomyosarcoma RD cells, human neuroblastoma SK-N-SH cells, and human glioblastoma U251 cells, in which we observed significantly reduced viral RNA replication after LAMTOR3 KO or knockdown (Fig. S2 A; and Fig. 2, I and J). Here, LAMTOR3 is linked to neuroblastoma.