CD4 and neoplasm: The researchers furnished the AAV vector with pDNA encoding a third‐generation CD4‐CAR, and upon single infusion into a humanized NOD.Cg‐Prkdcscid Il2rgem26/Nju HuPBL (NCG‐HuPBL) mouse model of human CD4+ T‐cell leukemia, the AAV reprogrammed sufficient numbers of potent in vivo CD4‐reactive CAR‐Ts to result in tumor eradication.