Additionally, an elevated proportion of T cells within tumors post‐infusion suggested that HER2‐CAR‐Raw264.7 disrupted the tumor extracellular matrix, facilitating deep infiltration of T cells into the TME.[75] Alternatively, J774A.1 cell line also serves as a valuable macrophage model.[76] In 1968, researchers from the National Cancer Institute first isolated the J774A.1 cell line from a macrophage tumor of a female BALB/cN mouse. The gene discussed is ERBB2; the disease is neoplasm.