CORT combined with CRS significantly reduced levels of three neurotransmitters (5‐HT, DA and GABA) and anti‐inflammatory factor IL‐10 (both p < 0.01), increased three HPA axis hormones (CRH, ACTH and CORT), and two proinflammatory factors (IL‐1β and TNF‐α) in peripheral blood (both p < 0.001). The gene discussed is POMC; the disease is congenital rubella syndrome.