Based on these findings, we demonstrated that sEH inhibition reduced pro‐inflammatory processes in vitro and in vivo models, being the eIF2α/CHOP, an undescribed implicated neuroprotective pathway that collaborates improving cognition and AD hallmarks in 5XFAD mice model by favoring synaptic plasticity, modulating ISR, and apoptosis (Figure 9). This evidence concerns the gene DDIT3 and Alzheimer disease.