Based on these findings, we demonstrated that sEH inhibition reduced pro‐inflammatory processes in vitro and in vivo models, being the eIF2α/CHOP, an undescribed implicated neuroprotective pathway that collaborates improving cognition and AD hallmarks in 5XFAD mice model by favoring synaptic plasticity, modulating ISR, and apoptosis (Figure 9). The gene discussed is EIF2A; the disease is Alzheimer disease.