Moreover, activated microglial cells produce various mediators, including inducible nitric oxide synthase (iNOS), nitric oxide (NO),27, 28 pro‐inflammatory cytokines (such as TNF‐a), and anti‐inflammatory cytokines (such as TGF‐a),29 collectively leading to complex immune reactions in the brains of patients with stroke,16, 30, 31, 32 including reactions with contradictory effects.33, 34, 35. This evidence concerns the gene NOS2 and Stroke.