Generalized myokymia and neuromyotonia are most commonly observed in humans as an immune‐mediated disorder, in which there is an immune response against proteins (CASPR2 or LG1) tightly complexed to voltage‐gated potassium channels (Kv1.1, 1.2 and 1.6 encoded by KCNA1, 2 and 6) of the peripheral nerve.1, 2. The gene discussed is KCNA1; the disease is Isaacs syndrome.