LOXL1 and pelvic organ prolapse: Importantly, the link between LOXL1 deficiency and pelvic organ prolapse reported in mice led to a study on the risk of PEX in women with pelvic organ prolapse, which found that diagnosis of PEX was increased by 1.56-fold in women with pelvic organ prolapse compared to that in unaffected individuals (Wirostko et al., 2016).