In addition to both genders suffering from increased rectal prolapse with age, it was reported that Loxl1−/− female mice on a mixed background display pelvic organ prolapse 2 days postpartum, with retraction at day 14; but with permanent damage to the pelvic floor (Liu et al., 2004; Li et al., 2020). The gene discussed is LOXL1; the disease is pelvic organ prolapse.