When Loxl1 null mice were first generated in 129S×C57BL/6 chimeras, Liu et al. reported that these animals had mild rectal prolapse and females presented pelvic organ prolapse 1-2 days postpartum, with prolapse retraction over time but permanent pelvic tissue damage (Liu et al., 2004, 2006). Here, LOXL1 is linked to pelvic organ prolapse.