LMX1B and glaucoma: These contrasting findings between 129S and BL/6 mice were observed previously in mice carrying a Lmx1b mutant allele on the BL/6 background, which were prone to develop abnormal IOPs, severe anterior segment developmental anomalies and optic nerve damage compatible with glaucoma, whereas 129S mice were resistant to developing these phenotypes (Tolman et al., 2021).