High PAI-1 levels were associated with increased risk of VTE (sHR 3.79, 95%CI 1.40–10.28) (Table 4), and DVT (sHR 3.00, 95%CI 0.95–9.47) in multivariable models adjusting for age at leukemia diagnosis, sex, race/ethnicity, acute leukemia type, BMI, history of VTE and comorbidities. The gene discussed is SERPINE1; the disease is leukemia.