The median age of onset — unlike most other germline syndromes — is similar to the expected disease onset in sporadic disease: 67 years (n=328) in DDX41 germline mutated AML patients and 68 years (n=326) in MDS patients (Figure 1B), which is congruent with the average age of onset for AML (68 years, https://seer.cancer.gov/statfacts/html/amyl.html) and MDS (71 years) patients (70). This evidence concerns the gene DDX41 and myelodysplastic syndrome.