It has been reported that the Special AT-rich Binding Protein-2 (SATB2), which was one of several crucial nuclear matrix-associated proteins (NMPs), directly binds to the matrix attachment regions (MARs) sequence of the FOXM1 gene, thereby recruiting CBP to the MAR, which in turn activated FOXM1 expression, promoting the proliferation of glioma stem cells (GSCs) (Tao et al., 2020). The gene discussed is SATB2; the disease is central nervous system cancer.