Sato et al. (2021) uncovered that histological characteristics depend on the site of development, and a solid-to-acinar transition (SAT) could be induced by the tumor microenvironment. Their findings demonstrated that cancer-associated fibroblasts (CAFs) activate TGF-β signaling to remodel tumor tissues, ultimately determining the histological pattern of LUAD. Nguyen et al. (2022) observed distinct gene expression patterns between the lepidic and solid subtypes, while the remaining subtypes showed similarity in terms of gene expression. Here, TGFB1 is linked to neoplasm.