The acute PTZ‐induced seizure model we employed offered valuable insights into the effects of anti‐PD‐1 treatment on immediate responses, and seizure susceptibility, however, was limited for understanding the long‐term effects of the PD‐1 monoclonal antibody on the progression of chronic epilepsy, the complexities of which include alterations in synaptic plasticity, network activity, and neuroinflammation.59 The gene discussed is PDCD1; the disease is epilepsy.