Improve sepsis‐induced lung injury by upregulated miRNA‐140‐5p expression; Improve sepsis‐induced acute kidney injury in rats, and attenuate the LPS‐induced kidney tubular epithelial cells apoptosis via modulating NOX4/PTEN/AKT pathway; Inhibit SIRT1‐dependent activation of NLRP3 inflammasomes to ameliorate LPS‐induced cardiac dysfunction. Here, PTEN is linked to Sepsis.