For instance, the use of inhaled corticosteroids (ICS) can exert anti‐inflammatory effects in dual and triple therapies; however, it may present inconsistent therapeutical outcomes and cause side‐effects, such as osteoporosis and increased risk of infection29, 30; inhibition of cytokines (e.g., IL‐4, IL‐5, and IL‐13) seems feasible, but long‐term administration and high cost hinder their clinical application.31 This evidence concerns the gene IL13 and osteoporosis.