In addition, the effectors of NLRP3 inflammasome, such as interleukin (IL)‐1β, NLRP3, and caspase‐1 are found to be elevated in plasma of COPD patients and IL‐1β combined with white blood cells, and fibrinogen shows predictive value in 89% of cases.6 This evidence concerns the gene NLRP3 and chronic obstructive pulmonary disease.