The multivariable analysis of the dry syndrome patients infected with H. pylori displayed hypergammaglobulinemia (odds ratio [OR], 0.354; 95% confidence interval [CI], 0.189‐0.663), total cholesterol (OR, 1.158; 95% CI, 0.856‐1.550), hypertension (OR, 0.227; 95% CI, 0.114‐0.455), Female sex (OR, 5.778; 95% CI, 1.458‐22.9), anti‐SSA/Ro60 positive (OR, 2.384; 95% CI, 233‐4.645), γ‐GT (OR, 0.99; 95% CI, 0.99‐1.00) and alkaline phosphatase (ALP, OR, 1.00; 95% CI, 0.99–1.00) levels. Here, TRIM21 is linked to hypertensive disorder.