In this framework, the multivariate logistic regression model analysis showed that the independent risk factors of H. pylori infection in pSS included hypergammaglobulinemia (OR, 0.354; 95% CI, 0.189‐0.663), hypertension (OR, 0.227; 95% CI, 0.114‐0.455), female sex (OR, 5.778; 95% CI, 1.458‐22.9), anti‐SSA/Ro60 positive (OR, 2.384; 95% CI, 233‐4.645), γ‐GT (OR, 0.99; 95% CI, 0.99‐1.00). This evidence concerns the gene TRIM21 and Hypertension.