In comparison among various histopathological subgroups, a phenomenon of positive histopathology, along with higher levels of IgG, ANA, SSA, Ro52, SSB, and uric acid, were observed in most of the H. pylori‐infected pSS patients, indicating a strong correlation between the pathological characteristics of the patients and the severity of the disease. Here, TRIM21 is linked to peeling skin syndrome.