In addition, the inhibitory effects of BIRC2 on the elevated ROS and MDA and the decreased SOD and GSH‐Px in LPS‐mediated C28/I2 cells were partly weakened by TRADD overexpression (Figure 6A–E), suggesting that TRADD overexpression could weaken the protective role of BIRC2 knockdown against oxidative stress during RA. The gene discussed is TRADD; the disease is rheumatoid arthritis.