SOD1 and rheumatoid arthritis: In addition, the inhibitory effects of BIRC2 on the elevated ROS and MDA and the decreased SOD and GSH‐Px in LPS‐mediated C28/I2 cells were partly weakened by TRADD overexpression (Figure 6A–E), suggesting that TRADD overexpression could weaken the protective role of BIRC2 knockdown against oxidative stress during RA.