To explore the relationship between SAMD1 and APS, we first detected the expression of SAMD1 by qRT‐PCR in the collected serum samples from 58 APS patients and 46 healthy women, and the results concluded that SAMD1 expression was lower in the serum of APS patients (Figure 1B,C, p < .05). Here, SAMD1 is linked to autoimmune polyendocrinopathy.