PANK2 and pantothenate kinase-associated neurodegeneration: Diagnosis is made based on the clinical history and MRI results (the “eye of the tiger” sign demonstrated iron accumulation in the brain), and recently, WES has been used to reduce the time and improve diagnosis efficiency.[7] The PANK2 gene (NM_153638.4, OMIM#606157) was identified as the causative gene of the PKAN disease.