HSPG2 and liver cancer: HBV gene mutation combined with GGT has been to have a certain diagnostic value for liver cancer.[17] In the present study, the ROC curve of the HBV gene mutation and GGT and GGTII for PLC and early PLC diagnosis revealed that GGT had a good clinical diagnostic efficiency for PLC and early PLC, whereas GGT exhibited poor clinical diagnostic performance for PLC and early PLC.