The characteristic brain lesions of NMOSD typically occur in areas abundant in AQP-4, including the periependymal regions surrounding the lateral ventricles, and the cerebral aqueduct.[7] These lesions are the anterior border of the thalamus, hypothalamus, and midbrain.[7] NMOSD frequently invades the area postrema and nucleus tractus solitarius, the dorsal medulla oblongata adjacent to the fourth ventricle.[7] When periependymal lesions surrounding the lateral ventricles are affected in NMOSD, SIADH, symptoms such as narcolepsy, and changes in body temperature can occur. This evidence concerns the gene AQP4 and inappropriate ADH syndrome.