Clinical statistics show that 10% to 30% of the patients with AS have cardiovascular involvement.[15] Common manifestations include conduction block, valve disease, cardiomyopathy, etc. Meanwhile, the high inflammatory state of AS leads to abnormal blood lipid metabolism and increased cardiovascular risk.[16–19] Whether GK angle is an independent influencing factor of cardiac structure and function in the patients with AS has not been determined. The gene discussed is GK; the disease is cardiomyopathy.