We screened 109 overlapping DEGs in osteomyelitis and DFU, 12 of which were core genes, including CXCL9, CXCL10, CXCL13, CXCR2, FCGR3B, IL1B, IL8, LCN2, MMP1, MMP3, MMP9, and S100A. Here, CXCL10 is linked to osteomyelitis.