Furthermore, patients with previous history of DFU are more likely to develop osteomyelitis than patients without DFU.[1] Osteomyelitis and DFU both affect the inflammatory milieu, including inflammatory responses and immune responses, inflammatory chemokines and cytokines such as serum tumor necrosis factor (TNF)-α, interleukin (IL) 1β, and IL8.[2] Although DFU are considered a risk factor for osteomyelitis, the common pathogenesis of these 2 diseases remains poorly studied. Here, TNF is linked to osteomyelitis.