Osteoblasts increase MMP1 expression under the regulation of IL-1 alpha, that the frequency of MMP1 (-1607 2G/2G) genotype in OM patients exhibits, resulting in increased levels of MMP1 2G allele in OM patients, and further promoting local healing of osteomyelitis.[31] In addition, it has also been discovered that MMP1 can contribute to a reduced risk of osteomyelitis.[32] In wound healing of DFU, a variety of cells, including fibroblasts, basal cells, and vascular endothelial cells, express MMP1. This evidence concerns the gene MMP1 and ocular melanoma.