We screened 109 overlapping DEGs in osteomyelitis and DFU, 12 of which were core genes, including CXCL9, CXCL10, CXCL13, CXCR2, FCGR3B, IL1B, IL8, LCN2, MMP1, MMP3, MMP9, and S100A. The gene discussed is CXCR2; the disease is osteomyelitis.