Osteomyelitis is often associated with bone infections and is caused by Staphylococcus aureus, in which neutrophils play a key role in the inflammatory response.[3] In patients with osteomyelitis, altered neutrophil Bax genes, reduced spontaneous apoptosis, and prolonged survival are correlated and may play a role in the pathogenesis of osteomyelitis.[4] Neutrophils can store secreted tissue proteinase G (CTSG) in neutrophils, which can regulate inflammation and activate matrix metalloproteinase (MMPs).[5] CTSG can enhance susceptibility to osteomyelitis. The gene discussed is CTSG; the disease is osteomyelitis.