There was a study showed that anti-IL6 therapy decreased hip synovitis and osteoclastic bone resorption and increased new bone formation after ischemic osteonecrosis.[63] p53 protein, the product of TP53 gene, is a tumor suppressor that inhibits the growth of aberrant cells, sense and repair the damage of DNA.[64] P53 can significantly co-regulate the mitophagy in BMSCs, decrease the accumulation of damaged mitochondria in cells, resist stress-induced apoptosis and senescence, and improve the repair of early steroid-induced ONFH.[65]. Here, TP53 is linked to neoplasm.