PCBP1 and central nervous system cancer: Therefore, by silencing the expression of PCBP1-AS1 in glioma cells, the clonal formation ability of LN18 and T98G cells was significantly reduced, reducing the proliferation, invasion and migration of glioma cells.[40] Meantime, a key role of Inc RNA promoter region methylation in gliomas has been highlighted, but the specific factors that mediate methylation of the LncRNA promoter region have not been well studied.