AKT1 and hepatocellular carcinoma: Which in turn affect the expression of PCBP1 downstream genes PRL-3 and p -AKT (pT308 and pSer473).[20] When the expression of PCBP1-AS is significantly enhanced, the phosphorylated active forms of PRL-3 and AKT in Hepatocellular carcinoma cellula are increased, and the expression levels of PRL-3 and AKT phosphorylated active forms in HCC cells can be sharply reduced when PCBP1-AS1 is reduced.