It is also the second leading cause of cancer-related death.[41] Late treatment of colon cancer still faces great challenges, and dysregulation of cellular metabolism has become a key hallmark of cancer.[42] Numerous research evidence suggests that mRNA and long noncoding RNAs play an significant role in the evolution of CRC.[43] The study found that PCBP1-AS1 up-regulation can isolate several mi RNAs such as has-miR-582-5p and has-miR-198. This evidence concerns the gene PCBP1 and cancer.