PCBP1-AS1 can bind and interact with AR proteins., During CRPC, up-regulation could first promote the binding of PCBP1-AS1 to ubiquitin-specific peptidase 22 (USP22) and the NTD structural domain of AR/AR-V7, and subsequently promote the stability of the AR/AR-V7 complex, inhibit AR ubiquitination, and promote the resistance of cancer cells to enzalutamide during CRPC treatment. This evidence concerns the gene USP22 and cancer.