The ceRNA hypothesis has important mechanisms that explain how LncRNAs can regulate protein-coding genes and regulate disease progression after competitive binding to miRNAs.[55] Dysregulation of LncRNAs such as PCBP1-AS1, UCA1 and SNHG16 in CRC can isolate several miRNAs such as has-miR-582-5p and has-miR-198 and promote proliferation, invasion and drug resistance in Colorectal Cancer cells. Here, PCBP1 is linked to colorectal cancer.