Tumor immune escape is a phenomenon in which tumor cells use a variety of strategies to avoid being identified and attacked by the host immune system, enabling them to endure and develop.[71] HIF-1α upregulation has importance in tumor immune evasion for hypoxic environments.[72] In TNBC, HIF-1α hinders the tumor-killing activity of immune effector cells by major regulatory cytokines, immune checkpoint molecules, and cell transcription factors. Here, HIF1A is linked to neoplasm.