It has been reported that Cc increases the total antioxidant capacity, and glutathione peroxidase enzymes in serum of Mn-exposed rats with high dose of Cc treatment, which increased the ability of rats to resist external stimuli.[11] In KEGG pathway enrichment analysis, pathways of neurodegeneration_multiple diseases and Alzheimer disease may be the main pathways for Cc treatment of Mn-induced nervous system diseases. This evidence concerns the gene CXCR1 and early-onset autosomal dominant Alzheimer disease.