PTGS2 and early-onset autosomal dominant Alzheimer disease: Multiple single-nucleotide polymorphism have been described in the promoter region of PTGS2 gene, which may regulate its transcription, but only one polymorphism is located at position 765 G/C, and the stimulator-1 binding site inferred by a has been proven to be functional.[22] PTGS2 polymorphism is associated with reduced risk of Alzheimer disease.[22,23] Michele et al reported that the polymorphism of the PTGS2 gene is associated with an unrelated incidence of stent restenosis.[24] Nevertheless, the potential of PTGS2 for atherosclerosis still deserves further attention.