Some studies have showen that inhibiting NOS1 can prevent neuronal degeneration.[25,26] Another study demonstrated that deleting the NOS2 gene protects against Mn-induced neurological dysfunction in mice.[27] As important substances that affect oxidative stress, NOS1 and NOS2 are an important factors in the occurrence and development of Mn-induced nervous system diseases. This evidence concerns the gene NOS1 and nervous system disorder.