By binding its receptors, CXCL8 accelerates CRC cell proliferation, invasion, migration, and angiogenesis through the activation of the PIK3/Akt, MAPK, STAT3, and ERK1/2 signaling pathways.[34] ACKR4, on the other hand, is a shared hub gene in the viral protein interaction with cytokine and cytokine receptor and cytokine-cytokine receptor interaction signaling pathways. This evidence concerns the gene MAPK3 and colorectal carcinoma.