Gene expression has been widely used in the discovery of prognostic biomarkers of CRC.[4] The expression levels of several genes such as PD-L1, STC2, LAYN, ApoE, and ZYX showed associations with poor OS of CRC.[4] Our study focused on KIFC2, a member of the kinesin-14 family, and performed an integrative bioinformatic analysis in TCGA and GEO datasets. The gene discussed is LAYN; the disease is colorectal carcinoma.