The incidence of hypercalcemia, hyperphosphatemia, vascular calcification, and adynamic bone disease has also increased significantly due to the aggressive clinical use of bioactive vitamin D and vitamin D receptor agonists and excessive suppression of PTH.[17] Calcium balance is whole-body calcium retention or deficit calculated by subtracting total body calcium losses from total calcium inputs. This evidence concerns the gene PTH and hypercalcemia disease.