IL6 and atherosclerosis: In addition, polymorphism studies of the IL-6 gene showed that polymorphisms at the -572G/C, -597G/A, -1363G/T, and -2954G/C loci have a synergistic effect on IL-6 gene transcription[23] and that IL-6 genotypes may be associated with the development of juvenile systemic arthritis, Kaposi’s sarcoma, and atherosclerosis.[37–39]